Our Team

As experts with a reputation for excellence, Integrium has been able to attract and retain the best and the brightest in the clinical research and development field. Together with our founders, they bring valuable insight to every project, helping clients successfully navigate the complexities of each unique clinical trial.

Executive Management Team

David H. G. Smith, MD

Founding Partner, Chief Medical Officer

Joel M. Neutel, MD

Director of Research & Principal

Mark Powers

Executive Director, Capital Solutions

Michael Loftus, MPA

Executive Director, Business Development

Carmen Margaritescu, MD

Medical Director

Kenneth E. Homer, MS

Director of Biometrics

Jessica Coutu

Senior Vice President, Clinical Operations


David H. G. Smith, MD

Founding Partner, Chief Medical Officer

David H. G. Smith, MD is one of the founding partners of Integrium and serves as the Chief Medical Officer. In this role, he oversees the Medical Safety department, which provides pharmacovigilance and medical monitoring services. He also works closely with clients on program planning, protocol development and other key clinical matters. Dr. Smith brings substantial experience in clinical research and management to the operational capabilities of Integrium. His leadership has provided the visionary growth and ethical service bias essential in contract services outsourcing.

“Our existence and continued growth has always been in response to client need,” according to Dr. Smith. “From the very beginning, our clients, both in the clinical development and marketing sectors of industry, came to us first for advice, and then for focused and efficient effort in the execution of well designed study programs. I am proud of the way Integrium has refined the critical relationship of scientific quality, regulatory muster and marketing relevance —understanding that all are essential to product advancement.”

Dr. Smith completed his training in internal medicine and cardiovascular disease at the Veterans Affairs Medical Center, Long Beach, California and at the University of California, Irvine.

Dr. Smith has participated actively in research in the fields of hypertension, hyperlipidemia, diabetes, ischemic heart disorders and exercise stress testing. He has special interests in the study of the renin-angiotensin system, disorders of arterial compliance and endothelial dysfunction, 24-hour ambulatory blood pressure monitoring and the general pharmacotherapy of cardiovascular disorders. In addition to acting as Chief Medical Officer on a number of large international, multicenter clinical trials, he has authored numerous journal articles, abstracts, and book chapters and has formally presented at many scientific meetings. Dr. Smith is a member of several specialty organizations and has been designated as a Specialist in Clinical Hypertension.

Along with his leadership role, Dr. Smith has served many clients in the area of scientific and regulatory consultation and has further assisted sponsors with representation and participation in meetings held with the US Food and Drug Administration, as well as international regulatory authorities.

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Joel M. Neutel, MD

Director of Research & Principal

Dr. Neutel has had extensive experience serving the biopharmaceutical industry in the areas of clinical and academic research, as well as marketing strategic planning. Dr. Neutel maintains major responsibility as Director of Research at the Orange County Research Center in Orange County, California and at the Memorial Research Medical Clinic in Long Beach, California, where he has served as Study Principal Investigator on many multinational cardiovascular trials.Read More

After receiving his medical degree at the University of Witwatersrand in Johannesburg, South Africa, Dr. Neutel completed his internship and residency in internal medicine at the Veterans Administration Medical Center in Long Beach and The University of California, Irvine. Dr. Neutel has authored numerous abstracts, journal articles and book chapters. He has conducted extensive research in such disciplines as cardiovascular medicine, endocrinology, and central nervous system disorders, with special attention to the pharmacotherapy of the diseases in these areas.

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